IPS细胞来源神经细胞
2016-11-09

人IPSC来源神经干细胞 (阿尔海默氏病PSEN-1 A246E)

Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN-1 A246E)

Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E mutation). 1 vial of Neural Stem Cells (1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL).

产品描述

Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Axol NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.
Axol NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Axol NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Axol NSCs can be maintained in culture long-term (>1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.

Starting materialDermal fibroblast
Donor genderFemale
Donor age at sampling31 yrs
HLA serotypeA2 A24, B18(Bw6) B44(Bw4), Cw2 Cw12
Reprogramming methodEpisomal vector
Induction methodMonolayer & chemically defined medium
Genetic modificationNone
Size≥1.5 million cells
Kit componentsKit includes ≥1.5M viable cryopreserved iPSC-derived Neural Stem Cells (PSEN-1 Mutation A246E) and 1 x 30 mL Neural Plating-XF Medium (ax0033). .
Cell typeiPSC-derived neural stem cells
Growth propertiesAdherent
MutationPresenilin 1 (PSEN1) A426E
Disease informationThe donor (Caucasian) was clinically affected with Alzheimer's Disease. Onset of the disease occurred at age 45.
Shipping conditionsDry ice
Storage conditionsLiquid nitrogen
说明书
参考文献
订购信息
公司名称 Company Name

福建三一造血造血技术有限公司

Fujian StemEry Bio-tech Co.,Ltd.

联系人 Contact
陈经理 Jack Chan
联系电话 Telephone No.
13599953307,400 1155 980
电邮 E-mail
sales@stemery.cn
网站 Site
www.stemery.cn
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