IPS细胞来源神经细胞
2016-11-09

基因改造iPSC来源的神经干细胞MAPT V337M HOM

AxolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOM

axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOM (1.5 million cells) and Neural Plating-XF Medium (30 mL).

产品描述

Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the MAPT gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details. 

The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer's disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju et al., 1999) and makes the MAPT/tau protein more susceptible to hyperphosphorylation (Alonso et al., 2004). 

Starting materialDermal fibroblast
Donor genderFemale
Donor age at sampling64 yrs
KaryotypeNormal
Reprogramming methodEpisomal vector
Induction methodMonolayer & chemically defined medium
Genetic modificationHomozygous for the MAPT V337M mutation (GTG>ATG)
Genetic modificationContains a puromycin resistance cassette (intronic)
Size≥1.5 million cells
Kit components1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)
Growth propertiesAdherent
Shipping conditionsDry ice
Storage conditionsLiquid nitrogen
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公司名称 Company Name

福建三一造血造血技术有限公司

Fujian StemEry Bio-tech Co.,Ltd.

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