axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOM (1.5 million cells) and Neural Plating-XF Medium (30 mL).
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the MAPT gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer's disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju et al., 1999) and makes the MAPT/tau protein more susceptible to hyperphosphorylation (Alonso et al., 2004).
|Starting material||Dermal fibroblast|
|Donor age at sampling||64 yrs|
|Reprogramming method||Episomal vector|
|Induction method||Monolayer & chemically defined medium|
|Genetic modification||Homozygous for the MAPT V337M mutation (GTG>ATG)|
|Genetic modification||Contains a puromycin resistance cassette (intronic)|
|Size||≥1.5 million cells|
|Kit components||1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)|
|Shipping conditions||Dry ice|
|Storage conditions||Liquid nitrogen|
公司名称 Company Name
Fujian StemEry Bio-tech Co.,Ltd.
陈经理 Jack Chan
联系电话 Telephone No.
13599953307，400 1155 980